Sclerostin antibody preserves the morphology and structure of osteocytes and blocks the severe skeletal deterioration after motor-complete spinal cord injury in rats.
RatSpinal cord injuryUnspecifiedWistarMale25 mg/kg per weekBeginning 7 days after injury
Model: Motor-complete spinal cord injury with disuse bone loss
Spinal cord injury reduced distal femur bone mineral density by about 25% and trabecular bone volume by about 67%; sclerostin antibody completely prevented these losses, markedly increased bone formation, and restored osteocyte number and morphology.
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