Stimulation of cutaneous wound healing by an FPR2-specific peptide agonist WKYMVm.
RatWoundSprague-DawleyMaleTopical application onto the woundApplied to cutaneous wounds during healing
Model: Cutaneous wound in streptozotocin-induced diabetic rats
Topical WKYMVm stimulated capillary and arteriole formation with a maximum at day 6, acutely increased CD68-positive macrophage infiltration, and accelerated re-epithelialisation and granulation tissue formation in diabetic rat wounds.
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