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← Studies/PMID 25973006
PRECLINICAL PUBLICATION · 2015

BQ-869, a novel NMDA receptor antagonist, protects against excitotoxicity and attenuates cerebral ischemic injury in stroke.

Rat / Ischaemia-reperfusion

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PMID 25973006 ↗2015Reported benefit

BQ-869, a novel NMDA receptor antagonist, protects against excitotoxicity and attenuates cerebral ischemic injury in stroke.

RatIschaemia-reperfusionCerebral (MCAO/stroke)Sprague-Dawley

Model: Middle cerebral artery occlusion (reported as MACO) focal cerebral ischaemia in rats, with companion in vitro NMDA excitotoxicity work in hippocampal pyramidal neurons

BQ-869 blocked NMDA receptors in a concentration- and dose-dependent manner, reduced NMDA-induced calcium influx, improved motor ability, decreased infarct size and reduced mortality in rats with focal cerebral ischaemia.

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.55. Machine-extracted fields require source verification.