Divergent effects of RIP1 or RIP3 blockade in murine models of acute liver injury.
MouseChemical/toxinC57BL/6 (H-2K) wild type, RIP3 knockout and NLRP3 knockoutMaleIntraperitoneal for inhibitors; concanavalin A intravenous, acetaminophen intraperitonealNecrostatin-1 1.65 per g body weight intraperitoneally; Z-I…Pretreatment before injury; a single dose of necrostatin-1s immediately before…
Model: Concanavalin A-induced autoimmune hepatitis and acetaminophen-induced acute liver injury in mice
RIP3 deletion was protective in both models. RIP1 inhibition with necrostatin-1 protected against acetaminophen injury with reduced NLRP3 inflammasome activation and sterile inflammation, but markedly exacerbated concanavalin A hepatitis with increased apoptosis, accelerated death and reduced survi…
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