PRECLINICAL PUBLICATION · 2015

The Secretome of Hydrogel-Coembedded Endothelial Progenitor Cells and Mesenchymal Stem Cells Instructs Macrophage Polarization in Endotoxemia.

Mouse / Endotoxin/LPS

Evidence by therapy association

Study details and outcomes are extracted in the context of a specific intervention. Separate associations are retained rather than silently merged.

Endothelial progenitor cells coembedded with renal mesenchymal stem cells in a hyaluronic acid-based hydrogel, with hypoxic preconditioning of the mesenchymal stem cells

PMID 25947337 ↗2015Reported benefit

The Secretome of Hydrogel-Coembedded Endothelial Progenitor Cells and Mesenchymal Stem Cells Instructs Macrophage Polarization in Endotoxemia.

MouseEndotoxin/LPS

Model: Lipopolysaccharide-induced acute kidney injury (endotoxaemia) in mice, with femoral ligation used to assess angiogenesis

Coembedded endothelial progenitor cells with hypoxically preconditioned mesenchymal stem cells gave additive improvement in medullary renal blood flow and proteinuria over endothelial progenitor cells alone, raised circulating M2 macrophages and reduced circulating cytokines and chemokines.

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