The Reg3alpha (HIP/PAP) Lectin Suppresses Extracellular Oxidative Stress in a Murine Model of Acute Liver Failure.
MixedChemical/toxinC57BL/6JIntravenous in vivo2.5 mg/kg in vivo; 0.24 micromolar in primary hepatocyte cu…Injected at various times after anti-CD95 challenge; effective when given 6 h p…
Model: Acute liver failure induced by intravenous anti-CD95 (Fas) antibody at 170 micrograms/kg, lethal for about 60 per cent of mice within 24 h; in vitro hepatocyte stress with TNF-alpha plus actinomycin D (20 ng/mL plus 50 ng/mL) or 1 mM hydrogen peroxide
Reg3alpha bound the fibrin network, suppressed the Fas-induced twofold rise in extracellular malondialdehyde within 30 min and reduced extracellular protein carbonylation by about 40 per cent; in vitro it held malondialdehyde at control levels and increased hepatocyte survival by 35 per cent, an ef…
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