Therapeutic effects of topical netrin-4 in a corneal acute inflammatory model.
RatBurnChemical / corrosiveTopical eye drops
Model: Corneal alkali burn inducing acute ocular surface inflammation in rats
Topical netrin-4 reduced fluorescein staining at days 4 and 7, resolved the corneal inflammation index by day 7, and lowered corneal inflammatory mediator and CD45 expression relative to saline.
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