Enhancing repair of full-thickness excisional wounds in a murine model: Impact of tissue-engineered biological dressings featuring human differentiated adipocytes.
MouseWoundFemaleApplied topically as a temporary dressing
Model: Full-thickness excisional cutaneous wounds in mice with a fluorescent (GFP-expressing keratinocyte) epidermis
Treated wounds closed slightly but significantly faster over 18 days with thicker granulation tissue (1.7-fold, P<0.0001), higher collagen content (1.3-fold, P<0.0104) and 2.2-fold greater neovascularisation (P<0.0002), while re-epithelialisation kinetics were similar between groups.
Extraction: extract · Supplied extraction confidence: 0.65. Machine-extracted fields require source verification.