Delayed Imatinib Treatment for Acute Spinal Cord Injury: Functional Recovery and Serum Biomarkers.
RatSpinal cord injuryContusionSprague-DawleyFemalen = 90 contusion injured rats plus 10 sham; 4 h delay pilot 5 v…Oral gavage250 mg/kg per day, divided one third in the morning and two…Treatment initiated 4, 8 or 24 h after injury
Model: Thoracic T10 contusion spinal cord injury using an NYU impactor, 10 g weight dropped from 12.5 mm (mild) or 25 mm (moderate)
With a 4 h delay after mild injury, imatinib improved week 10 BBB score (14.2 plus or minus 0.57 versus 12.2 plus or minus 0.24), BBB subscore (3.2 plus or minus 0.37 versus 1.2 plus or minus 0.31), regularity index (81.4 plus or minus 4.7 versus 48.7 plus or minus 6.7 per cent of normal) and bladd…
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