The Complement Receptor C5aR Controls Acute Inflammation and Astrogliosis following Spinal Cord Injury.
MouseSpinal cord injuryContusionC5ar knockout and wild-type mice, plus bone marrow chimeric miceAdministered during the first 7 days after injury, or continued into the chroni…
Model: Contusive spinal cord injury
C5aR signalling was injurious acutely but protective or reparative later. C5ar knockout mice initially recovered better but by day 14 onward had worse function, larger lesions, less myelin and more inflammation at 35 days. Antagonist treatment limited to the first 7 days improved recovery through t…
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