Post-ischaemic silencing of p66Shc reduces ischaemia/reperfusion brain injury and its expression correlates to clinical outcome in stroke.
MixedIschaemia-reperfusionCerebral (MCAO/stroke)C57BL/6 (wild-type)IntravenousAfter the ischaemic episode, upon reperfusion
Model: Transient middle cerebral artery occlusion with reperfusion
Post-ischaemic p66Shc knockdown preserved blood-brain barrier integrity and gave smaller lesion volumes, reduced neurological deficits and increased survival. In human brain microvascular endothelial cells, p66Shc silencing preserved claudin-5 during hypoxia and reoxygenation by reducing NADPH oxid…
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