The matrix metalloproteinase inhibitor RS-130830 attenuates brain injury in experimental pneumococcal meningitis.
RatOtherWistarn = n=40 RS-130830, n=42 vehicle controlintraperitoneal75 mg/kgstarted 3 h post infection
Model: Pneumococcal meningitis induced by intracisternal injection of live Streptococcus pneumoniae, with ceftriaxone started 18 h post infection
Cortical necrosis was significantly attenuated by RS-130830 while hippocampal apoptosis was unchanged. CSF IL-1beta and IL-10 at 18 h post infection were significantly lower, and weight loss and CSF leukocyte counts were significantly reduced in treated survivors.
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