Attenuation of traumatic brain injury-induced cognitive impairment in mice by targeting increased cytokine levels with a small molecule experimental therapeutic.
MouseTBIClosed-head / concussionC57BL/6Jmaleintraperitoneal1, 5 or 10 mg/kg (5 mg/kg used for efficacy studies)single dose at 3 h or 6 h post-injury for cytokine studies; extended paradigm s…
Model: Midline closed head injury (diffuse traumatic brain injury) using a stereotaxic electromagnetic impactor, 5.0 mm steel tip, velocity 5.0 m/s, dwell time 100 ms, impact depth 1.0 mm at ML 0.0 mm, AP -1.5 mm
A single 5 mg/kg dose at 3 h or 6 h post-injury reduced cortical IL-1beta at the 9 h peak by 58 to 63%, with dose-dependent suppression significant at 5 and 10 mg/kg and no effect on CCL2. Extended dosing (3 h, 6 h then daily for 7 days) rescued radial arm water maze performance and reduced IBA1, C…
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