Proneurotrophin Binding to P75 Neurotrophin Receptor (P75ntr) Is Essential for Brain Lesion Formation and Functional Impairment after Experimental Traumatic Brain Injury.
MouseTBIControlled cortical impactC57BL/6 background, including NGFR(-/-) mice lacking the proneurotrophin-binding site of p75NTR and NGFR(+/+) wild type littermatesmale and female
Model: Controlled cortical impact (CCI) traumatic brain injury
p75NTR mRNA was induced nine-fold by TBI. Genetic deletion of the proneurotrophin-binding site reduced lesion volume by 29% at 24 h and 21% at 5 days and improved motor coordination at 24 h. Pharmacological inhibition with TAT-Pep5 reduced lesion volume by 18% at 24 h.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.