Functional Recovery of Carbon Nanotube/Nafion Nanocomposite in Rat Model of Spinal Cord Injury.
RatSpinal cord injuryComplete transectionSprague-Dawleyfemaledirect injection into the epicentre of the lesion25 microlitres of 1, 10 or 100 microgram/mL nanocompositeone week after transection
Model: Complete transection spinal cord injury at the T9-T10 vertebral level
Nanocomposite administration decreased lesion volume and increased neurofilament-positive and corticospinal tract fibres in the lesion without increasing reactive gliosis (P < 0.001), and produced a modest improvement in hind limb locomotor recovery without inducing hyperalgesia.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.8. Machine-extracted fields require source verification.