TREM-1 Mediates Inflammatory Injury and Cardiac Remodeling Following Myocardial Infarction.
MixedIschaemia-reperfusionCardiacC57BL/6 mice including Trem-1 knockout mice; Wistar ratsmalen = n=20-22 per group for survival and left ventricular functio…
Model: Myocardial infarction from permanent and transient coronary ischaemia; parallel human cohort with acute myocardial infarction
TREM-1 was upregulated in ischaemic myocardium in mice and humans. Trem-1 genetic invalidation or pharmacological inhibition with LR12 dampened myocardial inflammation, limited neutrophil recruitment and MCP-1 production, reduced classical monocyte mobilisation, and improved left ventricular functi…
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