Effects of sphingosylphosphorylcholine against oxidative stress and acute lung ınjury ınduced by pulmonary contusion in rats.
RatCrushOther / unspecifiedWistarn = 8 animals in each of five groups (40 total)intraperitoneal2 micromolar/mL or 10 micromolar/mL dailyafter pulmonary contusion
Model: Acute lung injury induced by pulmonary contusion (blunt thoracic trauma)
The 2 micromolar dose significantly inhibited the rise in lung malondialdehyde and nitric oxide, attenuated depletion of superoxide dismutase, glutathione peroxidase and glutathione, and reduced inducible nitric oxide synthase positive and apoptotic cells, supported by histopathology. The 10 microm…
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