N-acetyl-L-leucine accelerates vestibular compensation after unilateral labyrinthectomy by action in the cerebellum and thalamus.
RatChemical/toxinSprague-DawleyMaleIntravenous24 mg intravenously per rat, equivalent to 60 mg/kg body we…After unilateral labyrinthectomy, with assessment before and on days 1, 3, 7 an…
Model: Unilateral chemical labyrinthectomy
Postural imbalance improved at day 7 with N-acetyl-DL-leucine (p<0.03) and N-acetyl-L-leucine (p<0.01) at 60 mg/kg, accelerating postural compensation by about 6 days, but nystagmus and head roll tilt were unchanged and lower doses had no significant effect.
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