NRF2 promotes neuronal survival in neurodegeneration and acute nerve damage.
MouseCrushPeripheral-nerve crushC57BL/6 and mutant strains used as retinal degeneration models
Model: Optic nerve crush, plus three models of photoreceptor degeneration
AAV-mediated NRF2 delivery was more neuroprotective than SOD2 or catalase for both photoreceptors and retinal ganglion cells, whereas PGC1a expression accelerated photoreceptor death.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.