Dual Therapeutic Effects of C-10068, a Dextromethorphan Derivative, Against Post-Traumatic Nonconvulsive Seizures and Neuroinflammation in a Rat Model of Penetrating Ballistic-Like Brain Injury.
RatTBIPenetrating / ballisticSprague-DawleyMaleContinuous infusion1.0, 2.5 and 5.0 mg/kg/hStarted after injury
Model: Penetrating ballistic-like brain injury
C-10068 dose-dependently reduced nonconvulsive seizure incidence by 40 to 50%, frequency by 20 to 70% and duration by 30 to 82%, and 5.0 mg/kg/h attenuated hippocampal astrocyte activation and perilesional microglial reactivity, but motor and cognitive function did not improve.
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