The effect of cyclosporine A in hemorrhagic shock model of rats.
RatHaemorrhage/shockControlledSprague-DawleyMaleIntravenous (tail vein)10 mg/kg or 50 mg/kgImmediately after the 90 min shock period
Model: Pressure-controlled haemorrhagic shock (mean arterial pressure 38 (1) mm Hg for 90 min) followed by transfusion of shed blood
Both cyclosporine A doses significantly prolonged survival, 50 mg/kg lowered plasma interleukin-6 and thiobarbituric acid-reactive substances, Akt, GSK-3beta and Bad phosphorylation increased, and mitochondrial ultrastructural change was less marked, although liver histological injury did not diffe…
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