Cyanidin-3-O-Glucoside Ameliorates Lipopolysaccharide-Induced Injury Both In Vivo and In Vitro Suppression of NF-kappaB and MAPK Pathways.

Cyanidin-3-O-Glucoside Ameliorates Lipopolysaccharide-Induced Injury Both In Vivo and In Vitro Suppression of NF-kappaB and MAPK Pathways.

Model: Lipopolysaccharide-induced acute respiratory distress syndrome model in mice; lipopolysaccharide-stimulated human umbilical vein endothelial cells in vitro

Cyanidin-3-O-glucoside pretreatment reduced pro-inflammatory cytokines, inflammatory cell infiltration, alveolar wall thickening and interstitial oedema, lowered malondialdehyde, myeloperoxidase and lung wet to dry ratio, and suppressed NF-kappaB and MAPK activation.

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