The chemical inhibitors of cellular death, PJ34 and Necrostatin-1, down-regulate IL-33 expression in liver.
MouseChemical/toxinC57BL/6Pretreatment before concanavalin A or poly(I:C) challenge
Model: Concanavalin A-induced and polyinosinic-polycytidylic acid-induced acute hepatitis, with CCl4-induced liver injury as an additional model
Pretreatment with necrostatin-1 and/or PJ34 significantly protected mice against concanavalin A liver injury as judged by transaminases, and down-regulated hepatocyte-specific IL-33 expression. PJ34 also reduced liver injury and IL-33 after poly(I:C) but gave no protection in CCl4-induced injury.
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