Anti-inflammatory effects of methanol extract of Canarium lyi C.D. Dai & Yakovlev in RAW 264.7 macrophages and a murine model of lipopolysaccharide-induced lung injury.
MouseEndotoxin/LPSMaleTreatment given in relation to LPS challenge; exact timing not stated in the ab…
Model: Lipopolysaccharide-induced acute lung injury in mice, with parallel LPS-stimulated RAW 264.7 macrophage experiments
Treatment significantly inhibited inflammatory cell recruitment and pro-inflammatory cytokine production in bronchoalveolar lavage fluid and reduced COX-2 expression and IkB and p65 phosphorylation. Lung histopathological changes induced by LPS were attenuated.
Extraction: extract · Supplied extraction confidence: 0.55. Machine-extracted fields require source verification.