Pharmacologically induced hypothermia attenuates traumatic brain injury in neonatal rats.
RatTBIControlled cortical impactWistarn = 5 to 8 per group for contusion volume quantificationIntraperitonealFirst bolus 2 mg/kg then one or two further injections at 1…First bolus 15 min after injury; delayed paradigms started at 1 h or 2 h after…
Model: Controlled cortical impact through a 3.5 mm craniotomy 2.0 mm right of the central suture, 3.0 mm flat tip, velocity 3 m/s, depth 2.0 mm, contact time 150 ms
A single bolus produced a dose-dependent 2 to 5 degree fall in body and brain temperature, and the 2 mg/kg plus 1 mg/kg regimen maintained mild hypothermia for at least 6 h without shivering. Treated pups had smaller contusion volumes, fewer TUNEL-positive and TUNEL/NeuN cells, reduced caspase-3 wi…
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