Thaliporphine derivative improves acute lung injury after traumatic brain injury.
RatTBIControlled cortical impactSprague-DawleyMalen = 5 per group per time point, with 5 sham-operated ratsIntraperitoneal10 mg/kg in 0.1 mL3 h or 4 h after traumatic brain injury
Model: Controlled cortical impact traumatic brain injury through a craniotomy, impact velocity 4 m/s and deformation depth 2 mm below the dura, with resulting acute lung injury
TM-1 given at 3 or 4 h after injury significantly reduced the lung wet to dry weight ratio and lung injury score at both 8 and 24 h, and attenuated the injury-induced rise in aquaporin 1 and aquaporin 4 mRNA and protein. Lung injury score and wet to dry weight ratio were positively correlated (r =…
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