Overexpression of Sox11 promotes corticospinal tract regeneration after spinal injury while interfering with functional recovery.
MouseSpinal cord injuryUnspecifiedC57BL/6 (including transgenic lines)FemaleBoth acute and chronic injury paradigms tested
Model: Spinal axon injury affecting dorsal root ganglion axons and corticospinal tract axons, studied in acute and chronic injury paradigms
Dorsal root ganglion and corticospinal tract neurons failed to upregulate Sox11 after spinal axon injury, whereas forced viral Sox11 expression reduced axonal dieback and promoted corticospinal sprouting and regenerative growth in both acute and chronic paradigms. Cortical Sox11 overexpression none…
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