NAMPT inhibitor and metabolite protect mouse brain from cryoinjury through distinct mechanisms.
MouseTBICryogenicBALB/cMale
Model: Cortical cryoinjury model of traumatic brain injury
Both FK866 and NMN reduced neuronal loss and lesion volume at 24 h and day 14. FK866 additionally attenuated astrocyte and macrophage/microglia activation and lowered NAD, whereas NMN restored NAD without anti-inflammatory effects.
Extraction: extract · Subtype source: llm · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.