PRECLINICAL PUBLICATION · 2015

Secreted ectodomain of sialic acid-binding Ig-like lectin-9 and monocyte chemoattractant protein-1 promote recovery after rat spinal cord injury by altering macrophage polarity.

Rat / Spinal cord injury

Evidence by therapy association

Study details and outcomes are extracted in the context of a specific intervention. Separate associations are retained rather than silently merged.

Secreted ectodomain of Siglec-9 (ED-Siglec-9) and monocyte chemoattractant protein-1 (MCP-1); also conditioned medium from human deciduous dental pulp stem cells

PMID 25673840 ↗2015Reported benefit

Secreted ectodomain of sialic acid-binding Ig-like lectin-9 and monocyte chemoattractant protein-1 promote recovery after rat spinal cord injury by altering macrophage polarity.

RatSpinal cord injuryContusionSprague-DawleyIntrathecal administration into the injured spinal cordAcute post-injury period

Model: Contusive spinal cord injury

Intrathecal MCP-1 plus ED-Siglec-9 induced M2-like macrophages and produced marked recovery of hindlimb locomotor function after spinal cord injury; the effect was abolished by CCR2 inactivation.

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.