PRECLINICAL PUBLICATION · 1989

The role of excitatory amino acids and NMDA receptors in traumatic brain injury.

Rat / TBI

Evidence by therapy association

Study details and outcomes are extracted in the context of a specific intervention. Separate associations are retained rather than silently merged.

Dextrorphan (non-competitive NMDA antagonist) and 3-(2-carboxypiperazin-4-yl)propyl-1-phosphonic acid (competitive NMDA antagonist)

PMID 2567056 ↗1989Reported benefit

The role of excitatory amino acids and NMDA receptors in traumatic brain injury.

RatTBIFluid percussionMaleAfter injury

Model: Fluid percussion traumatic brain injury

Injury raised extracellular glutamate and aspartate in proportion to severity, with reduced bioenergetic state and intracellular free magnesium. Both NMDA antagonists limited neurological dysfunction, and dextrorphan also improved bioenergetic state and intracellular free magnesium.

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.72. Machine-extracted fields require source verification.