Protective actions of PJ34, a poly(ADP-ribose)polymerase inhibitor, on the blood-brain barrier after traumatic brain injury in mice.
MouseTBIControlled cortical impactBALB/cMaleIntraperitoneal10 mg/kg5 min and 8 h after controlled cortical impact
Model: Controlled cortical impact traumatic brain injury
PJ34 attenuated blood-brain barrier permeability and brain oedema at 6 and 24 h, reversed NF-kappaB up-regulation, lowered myeloperoxidase activity and matrix metalloproteinase-9, increased tight junction and basal lamina proteins, and reduced neurological deficit, contusion volume and neuronal cel…
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