The effect of estrogen-related receptor alpha on the regulation of angiogenesis after spinal cord injury.
RatSpinal cord injuryContusionSprague-DawleyMaleInjection (route not specified in the abstract)First dose 30 min after contusion
Model: Acute traumatic spinal cord injury by modified Allen weight-drop contusion
XCT790 aggravated tissue damage, reduced ERRalpha-positive cells, repressed ERRalpha, VEGF and angiopoietin-2 expression and decreased vascular density and endothelial proliferation, indicating that ERRalpha mediates angiogenesis after spinal cord injury. The compound was used as a mechanistic bloc…
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.