Enhanced Resolution of Hyperoxic Acute Lung Injury as a result of Aspirin Triggered Resolvin D1 Treatment.
MouseOtherC57BL/6100 ngAfter the 48 h hyperoxia exposure, during 24 h of normoxic recovery
Model: Hyperoxic acute lung injury, exposure to at least 95% oxygen for 48 h
AT-RvD1 reduced oxidative stress, increased glutathione, decreased tissue inflammation, lung wet to dry ratio and bronchoalveolar lavage protein, and lowered apoptotic and NF-kappaB signalling after prolonged hyperoxia.
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