Dorsal root ganglion myeloid zinc finger protein 1 contributes to neuropathic pain after peripheral nerve trauma.
RatCrushPeripheral-nerve crushSprague-DawleyMalen = n=5 rats per siRNA group in the maintenance experimentMicroinjection into the injured dorsal root ganglionTargeting both the initiation and maintenance phases after chronic constriction…
Model: Chronic constriction injury of the sciatic nerve
Dorsal root ganglion MZF1 siRNA attenuated initiation and maintenance of mechanical, cold and thermal hypersensitivity without affecting locomotor function or basal responses, while MZF1 overexpression produced hypersensitivity in naive rats. MZF1 mediated the injury-induced loss of Kv1.2 and incre…
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