Combined mitigation of the gastrointestinal and hematopoietic acute radiation syndromes by an LPA2 receptor-specific nonlipid agonist.
MouseRadiationC57BL/6, with LPA2 knockout mice as controlsn = 14 mice per treatment group in the partial body irradiation…Subcutaneous1 mg/kg or 10 mg/kgFirst dose delayed to 26 plus or minus 2 h after irradiation, with mitigation s…
Model: Acute radiation syndrome from high-dose gamma irradiation, using partial body irradiation with hind limb shielding (for example 15.69 Gy at about 1.47 Gy/min) and total body irradiation (about 0.82 Gy/min)
DBIBB reduced mortality in wild-type but not LPA2 knockout mice. In the partial body irradiation model 30-day survival was 57% at 1 mg/kg and 93% at 10 mg/kg versus 93% lethality in controls, and in total body irradiation the 10 mg/kg cohort showed a 50% survival benefit. It increased crypt surviva…
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