PRECLINICAL PUBLICATION · 2015

Hematopoietic recovery of acute radiation syndrome by human superoxide dismutase-expressing umbilical cord mesenchymal stromal cells.

Mouse / Radiation

Evidence by therapy association

Study details and outcomes are extracted in the context of a specific intervention. Separate associations are retained rather than silently merged.

Human extracellular superoxide dismutase (ECSOD)-modified umbilical cord mesenchymal stromal cells

PMID 25618561 ↗2015Reported benefit

Hematopoietic recovery of acute radiation syndrome by human superoxide dismutase-expressing umbilical cord mesenchymal stromal cells.

MouseRadiationBALB/cMaleSystemic administration

Model: Acute radiation syndrome after sub-lethal irradiation

Systemically administered ECSOD-modified umbilical cord mesenchymal stromal cells protected mice from sub-lethal irradiation and improved survival by promoting multilineage haematopoietic recovery, associated with reduced superoxide and apoptosis.

Extraction: extract · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.