Androctonus australis hector venom contributes to the interaction between neuropeptides and mast cells in pulmonary hyperresponsiveness.
MouseChemical/toxinMaleBefore venom administration (depletion and receptor blockade)
Model: Acute lung injury and pulmonary oedema induced by subcutaneous Androctonus australis hector scorpion venom
Pulmonary oedema measured by Evans blue extravasation was completely inhibited in compound 48/80 treated animals and the inflammatory response to venom was markedly reduced, indicating that mast cells acting through the neurokinin 1 receptor mediate venom-induced lung injury.
Extraction: extract · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.