Protective effect of rhGLP-1 (7-36) on brain ischemia/reperfusion damage in diabetic rats.
RatIschaemia-reperfusionCerebral (MCAO/stroke)Sprague-DawleyMaleIntraperitoneal20, 40 and 80 micrograms/kgGiven before reperfusion
Model: Middle cerebral artery occlusion with reperfusion in type 2 diabetic rats (high-fat diet plus low-dose streptozotocin)
Treated groups showed lower neurological deficit scores, smaller percentage infarct volume, lower malondialdehyde, iNOS and blood glucose, and higher superoxide dismutase, glutathione peroxidase and eNOS, with more surviving neurons and increased vascular proliferation.
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