PRECLINICAL PUBLICATION · 2015

Role of p53-fibrinolytic system cross-talk in the regulation of quartz-induced lung injury.

Mouse / Chemical/toxin

Evidence by therapy association

Study details and outcomes are extracted in the context of a specific intervention. Separate associations are retained rather than silently merged.

Caveolin-1 scaffolding domain peptide (CSP)

PMID 25596429 ↗2015Reported benefit

Role of p53-fibrinolytic system cross-talk in the regulation of quartz-induced lung injury.

MouseChemical/toxinC57BL/6 wild-type and knockout strainsFemale

Model: Silica (crystalline quartz) dust exposure causing lung injury and silicosis

Silica exposure increased alveolar epithelial cell apoptosis with induction of p53 and PAI-1 and suppression of uPA. CSP inhibited PAI-1, restored uPA and prevented apoptosis by suppressing p53 activation.

Extraction: extract · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.