Adventitial CXCL1/G-CSF expression in response to acute aortic dissection triggers local neutrophil recruitment and activation leading to aortic rupture.

Adventitial CXCL1/G-CSF expression in response to acute aortic dissection triggers local neutrophil recruitment and activation leading to aortic rupture.

Model: Acute aortic dissection produced by angiotensin II infusion in mice preconditioned with a lysyl oxidase inhibitor (beta-aminopropionitrile)

Dissection developed within 24 h and about 70 per cent of mice died of aortic rupture. Anti-CXCR2 reduced neutrophil accumulation, lowered local and systemic interleukin-6 and limited aortic rupture, while interleukin-6 disruption suppressed dilatation and rupture without altering dissection incide…

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