Delivery of placenta-derived mesenchymal stem cells ameliorates ischemia induced limb injury by immunomodulation.
MouseIschaemia-reperfusionLimb / skeletal muscleFemaleIntramuscular transplantation into the injured hind limb
Model: Hind limb ischaemia as a model of peripheral artery disease
Placenta-derived mesenchymal stem cells reduced acute muscle fibre apoptosis, lessened fibrosis and improved running capacity, with reduced inflammatory cell infiltration and pro-inflammatory cytokines and increased IL-10.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.