Asef mediates HGF protective effects against LPS-induced lung injury and endothelial barrier dysfunction.
MixedEndotoxin/LPSAsef knockout mice and wild-type controls
Model: Lipopolysaccharide-induced acute lung injury and pulmonary endothelial barrier dysfunction
HGF protected the pulmonary endothelial monolayer against LPS-induced hyperpermeability, NF-kB activation, adhesion molecule expression and IL-8 production. These effects depended on Asef, since Asef knockdown and Asef knockout mice showed diminished HGF protection against lung inflammation and vas…
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