Short-term inhibition of DPP-4 enhances endothelial regeneration after acute arterial injury via enhanced recruitment of circulating progenitor cells.

Short-term inhibition of DPP-4 enhances endothelial regeneration after acute arterial injury via enhanced recruitment of circulating progenitor cells.

Model: Defined acute endothelial injury of the carotid artery

Sitagliptin prevented SDF-1alpha degradation, increased recruitment of CXCR4 positive progenitor cells and accelerated reendothelialisation without promoting neointimal or medial hyperplasia, with the effect reversed by AMD3100.

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