Transplantation of glial progenitors that overexpress glutamate transporter GLT1 preserves diaphragm function following cervical SCI.
MixedSpinal cord injuryContusionSprague-DawleyFemalen = At least 8 per group per time point for efficacy and 6 per…Intraspinal microinjection into the ventral horn at 1.5 mm depth at C3, C4 and C51.0x10^6 cells into the lesion epicentre plus two injection…Immediately after contusion
Model: Unilateral C4 hemicontusion with the Infinite Horizon impactor, 1.5 mm tip at 395 kdyn, after right-sided C4 laminectomy
GLT1-overexpressing astrocyte transplants reduced lesion size and motor neuron loss, increased intact dorsal hemidiaphragm neuromuscular junctions and improved diaphragm EMG and compound muscle action potential amplitudes relative to medium controls, with grip strength unchanged.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.92. Machine-extracted fields require source verification.