Prophylactic inhalation of L-alanyl-L-glutamine enhances heat shock protein 72 and attenuates endotoxin-induced lung injury in rats.
RatEndotoxin/LPSSprague-DawleyMaleInhalationProphylactic, 12 hours before lipopolysaccharide inhalation
Model: Acute lung injury induced by lipopolysaccharide inhalation
Glutamine inhalation increased lung HSP72 and, when given 12 hours before lipopolysaccharide, reduced lung injury score, lavage lactate dehydrogenase activity and neutrophil percentage.
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