The antioxidative, non-psychoactive tricyclic phenothiazine reduces brain damage after experimental traumatic brain injury in mice.
MouseTBIControlled cortical impactC57Bl6MaleSubcutaneous3 mg/kg (low dose) or 30 mg/kg (high dose)30 minutes after controlled cortical impact
Model: Pneumatic controlled cortical impact injury, with endpoints at 24 hours
Phenothiazine dose-dependently reduced lesion volume by about 20% at 3 mg/kg and 26% at 30 mg/kg and limited weight loss, with lower iNOS expression but no significant change in neurological score, Iba-1 cells or TNF-alpha.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.