HINT1 protein: a new therapeutic target to enhance opioid antinociception and block mechanical allodynia.
MouseOtherMaleIntracerebroventricularAfter establishment of chronic constriction injury
Model: Chronic constriction injury of the sciatic nerve producing neuropathic mechanical allodynia
A single intracerebroventricular dose of TpGc attenuated NMDA receptor function and alleviated mechanical allodynia for several days, and TpGc enhanced morphine antinociception while preventing tolerance.
Extraction: extract · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.