Therapeutic effect of human umbilical cord mesenchymal stem cells modified by angiotensin-converting enzyme 2 gene on bleomycin-induced lung fibrosis injury.
MouseChemical/toxinC57BL/6Malen = 100 mice, five groups of 20; five mice per group sacrificed…Injection, route not statedAfter bleomycin pretreatment; interval not stated
Model: Intratracheal bleomycin (40 mg/ml/kg) induced acute lung injury and pulmonary fibrosis
ACE2-uMSC injection significantly alleviated lung injury and reduced Ashcroft fibrosis scores at 14 and 28 days, lowering MDA, GSSG, TNF-alpha, IFN-gamma, TGF-beta, IL-1, IL-2, IL-6, hydroxyproline, collagen type 1 mRNA, MMPs and TIMPs while increasing SOD, GSH, ACE2 and IL-10. The combined constru…
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