Protection of intestinal injury during heat stroke in mice by interleukin-6 pretreatment.
MouseOtherC57BL/6MaleIntraperitoneal0.6 microgramsTwo hours before hyperthermia
Model: Severe hyperthermia (heat stroke) with incremental heating to a maximum core temperature of 42.4 degrees C, causing intestinal injury
IL-6 pretreated mice required about 25 minutes longer to reach maximum core temperature, were protected from duodenal villus injury and swelling, showed reduced gastrointestinal permeability and had significantly lower plasma TNF-alpha, MCP-1, RANTES and KC.
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