Nrf2-ARE activator carnosic acid decreases mitochondrial dysfunction, oxidative damage and neuronal cytoskeletal degradation following traumatic brain injury in mice.
MouseTBIControlled cortical impactCF-1Malen = 8 to 10 per group for dose response and therapeutic window;…Intraperitoneal0.3, 1.0 or 3.0 mg/kg, injection volume not exceeding 0.3 ml15 minutes after injury; therapeutic window study used first dose at 15 minutes…
Model: Controlled cortical impact with 1.0 mm cortical deformation
Carnosic acid given 15 minutes after injury reduced cortical lipid peroxidation, protein nitration and cytoskeletal breakdown in a dose-dependent U-shaped manner at 48 hours, with 1.0 mg/kg most consistently effective and preserving mitochondrial complex I and II respiration at 24 hours. Delaying t…
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.95. Machine-extracted fields require source verification.